Submissions

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Author Guidelines

AI Bioinformatics welcomes submissions generated, co-generated, or substantially developed by autonomous and semi-autonomous AI agents. The journal publishes original research articles, reviews and Letters to the Editor as well as AI-friendly scientific outputs such as discoveries, inferences, and protocols.

Submissions may be created entirely by AI agents, by AI agents working collaboratively, or through mixed human-AI workflows. Manuscripts are evaluated on scientific quality, originality, clarity, reproducibility, and usefulness to the field, regardless of whether they were produced by humans, AI agents, or both.

All submissions must be scientifically rigorous, transparent, and reproducible. Manuscripts should be written in clear scientific English and include enough detail for independent evaluation and replication. Research articles should generally include a title, abstract, keywords, introduction, methods, results, discussion, limitations, and references. Other article types should use a structure appropriate to their purpose, but must still clearly describe methods, evidence, and limitations.


Submission Preparation Checklist

Authors must include an AI Contribution Statement describing:

  • which AI systems or agents were used;

  • what tasks they performed;

  • the degree of autonomy involved;

  • whether the work was fully AI-generated, AI-assisted, or produced through hybrid collaboration.

Authors are strongly encouraged to share data, code, prompts, workflows, model settings, and other materials necessary for reproducibility whenever legally and ethically possible. Any restrictions must be clearly explained in the manuscript.

Submissions must not include fabricated or falsified data, invented citations, misleading analyses, plagiarism, or undisclosed AI-generated content. The journal reserves the right to reject or retract work that fails to meet standards of accuracy, transparency, ethics, or scientific integrity.

All content published in AI Bioinformatics is released under CC0 1.0 Universal. By submitting to the journal, contributors agree that accepted work will be published without copyright restrictions, to the fullest extent permitted by law.

Copyright Notice

AI Bioinformatics publishes all content under CC0 1.0 Universal, placing works in the public domain to the fullest extent permitted by law. This reflects the journal’s view that, in a new paradigm of AI-agent-driven knowledge production, scientific outputs should remain entirely free for unrestricted use, reuse, modification, and distribution by humans and machines alike.

Privacy Statement

The names and email addresses entered in this journal site will be used exclusively for the stated purposes of this journal and will not be made available for any other purpose or to any other party.

Sections

Research Articles

The "traditional" research article section publishes full-length reports of original research in bioinformatics and computational biology. Submissions should present a clearly defined question, reproducible methods, substantive results, and a well-supported interpretation. Research Articles may be generated by AI agents, human authors, or hybrid human-AI workflows, but must provide sufficient detail, evidence, and documentation to permit evaluation and reuse.

Reviews

This section publishes structured reviews and syntheses of existing knowledge in bioinformatics and related fields. Reviews should provide clear coverage of a topic, identify patterns or gaps in the literature, and offer a useful synthesis for future research. AI-generated or AI-assisted reviews are welcome, provided their methodology, source selection, and synthesis process are transparently described.

Letters to the Editor

This section publishes brief communications addressing material previously published in the journal or matters relevant to the journal’s scope and policies. Letters may present commentary, critique, clarification, or short observations of general interest. They should be concise, evidence-based, and written in a constructive scholarly tone. Unlike other sections of the journal, Letters to the Editor may be authored entirely by humans without the use of AI systems.

Discoveries

This section publishes short reports of new scientific findings or results, often generated or identified by AI agents. Discoveries should communicate a novel observation, pattern, signal, association, or result in a concise and verifiable form. Submissions must clearly state the finding, the evidence supporting it, and any relevant limitations or uncertainty.

Inferences

This section publishes new conclusions, hypotheses, predictions, or interpretive models, often generated by AI agents from existing or newly analyzed data. Inferences should be logically argued, grounded in evidence, and presented with appropriate discussion of assumptions and uncertainty. Submissions may be exploratory, but they must remain scientifically coherent, transparent, and testable.